2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19425
    NS-220 377731-45-8 98%
    NS-220 is an orally active PPARα agonist with high subtype selectivity, with EC50 values of 1.9×10-8 M, 9.6×10-6 M and >10-4 M for PPARα, PPAR γ and PPARδ, respectively. NS-220 is used in the research for hyperlipidemia or metabolic disorders in type-2 diabetes.
    NS-220
  • HY-19475
    Taprizosin 210538-44-6 98%
    Taprizosin (UK-338003) is an α-adrenoreceptor antagonist.
    Taprizosin
  • HY-19690
    Ritobegron hydrochloride 476333-91-2 98%
    Ritobegron, a prodrug of the active compound, KUC-7322, is a selective β3 -adrenoceptor agonist. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.
    Ritobegron hydrochloride
  • HY-19859
    AMG-222 tosylate 1163719-08-1 98%
    AMG-222 (tosylate) is a DPP-IV inhibitor that can be used in the research of type II diabete.
    AMG-222 tosylate
  • HY-21241
    Thiol-modifier C6 S-S CE phosphoramidite 148254-21-1 98%
    Thiol-modifier C6 S-S CE phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    Thiol-modifier C6 S-S CE phosphoramidite
  • HY-23201
    A1-Phytoprostane-I 1035557-09-5 98%
    A1-Phytoprostane-I is a cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants.
    A1-Phytoprostane-I
  • HY-24063
    Malonyl-L-Carnitine chloride 2417978-94-8 98%
    Malonyl-L-Carnitine (chloride) is an ester product.
    Malonyl-L-Carnitine chloride
  • HY-29316
    3'-O-Azidomethylene-dT 136041-38-8 98%
    3'-O-Azidomethylene-dT is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-Azidomethylene-dT
  • HY-33218
    3'-O-TBDMS-2'-dA(Bz) 51549-40-7 98%
    3'-O-TBDMS-2'-dA(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-TBDMS-2'-dA(Bz)
  • HY-41333
    6ECA 647011-80-1 98%
    6ECA is a selective TGR5 receptor activator with an EC50 of 3.44 μM. 6ECA shows no significant activity at FXR. 6ECA can be used for the study of diabesity.
    6ECA
  • HY-47393
    2'-O-TBDMS-rG(iBu) 182007-86-9 99.0%
    2'-O-TBDMS-rG(iBu) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-O-TBDMS-rG(iBu)
  • HY-48289
    PKA/AKAP-IN-2 304888-67-3 98%
    PKA/AKAP-IN-2 (15109) is a non-peptide inhibitor of the interaction between protein kinase A (PKA) and A kinase anchoring proteins (AKAP). PKA/AKAP-IN-2 can be utilized in research related to cAMP disturbance associated diseases.
    PKA/AKAP-IN-2
  • HY-48813
    Glycoursodeoxycholic acid 3-sulfate 133429-88-6 98%
    Glycoursodeoxycholic acid 3-sulfate is a glycine-conjugated sulfated bile acid 3-sulfate, which is produced by SULT2A1-mediated sulfation of glycoursodeoxycholic acid (HY-N1424) in the liver. Glycoursodeoxycholic acid 3-sulfate attenuates the anti-inflammatory effect of glycoursodeoxycholic acid and impairs the inhibitory effect on the IL-17 and NF-κB signaling pathways. Glycoursodeoxycholic acid 3-sulfate shows a significant correlation with aortic flow velocity and BNP in patients with aortic stenosis. Glycoursodeoxycholic acid 3-sulfate is mainly used in related studies such as quantitative analysis, quality control and biochemical experiments; it often serves as a reagent for metabolomics analysis and can also be applied to research related to aortic stenosis.
    Glycoursodeoxycholic acid 3-sulfate
  • HY-69262
    2-(Hexadecyloxy)-1,3-propanediol 1931-78-8 98%
    2-(Hexadecyloxy)-1,3-propanediol (1,3-Propanediol,2-(hexadecyloxy)-) is an ester product.
    2-(Hexadecyloxy)-1,3-propanediol
  • HY-76520
    Sitaxsentan 184036-34-8 98%
    Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension.
    Sitaxsentan
  • HY-A0185
    Calcium Gluceptate 29039-00-7 98%
    Calcium Gluceptate is a calcium supplement. Calcium Gluceptate can be used for hypocalcaemia research.
    Calcium Gluceptate
  • HY-B0700
    Rosiglitazone sodium 316371-83-2 98%
    Rosiglitazone sodium is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone sodium is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
    Rosiglitazone sodium
  • HY-B1045
    Chlorazanil hydrochloride 2019-25-2 98%
    Chlorazanil hydrochloride is an orally effective diuretic.
    Chlorazanil hydrochloride
  • HY-B1670
    (-)-Isoproterenol 51-31-0 98%
    (-)-Isoproterenol (Levisoprenalinel) is the R-isomer of Isoproterenol. (-)-Isoproterenol can reduce the cleavage of caspase 3 and TNFα levels in retinal endothelial cells (REC). (-)-Isoproterenol can be used for the study of diabetic retinopathy.
    (-)-Isoproterenol
  • HY-B1713
    Ornithine 616-07-9 98%
    Ornithine ((±)-Ornithine) is a non-essential amino acid. Ornithine is an intermediate in urea cycle and acts as a substrate for these rate limiting enzymes ornithine transcarbomylase, ornithine aminotransferase and ornithine decarboxylase producing citrulline, proline and polyamines, respectively. Ornithine can be used in the research of hyperornithinemia, hyperammonemia, and cancer.
    Ornithine
Cat. No. Product Name / Synonyms Application Reactivity